Learning the ABCs of ADCs: A treatment option for ovarian cancer and breast cancer

By AbbVie September 30, 2024

If you’re facing ovarian cancer or breast cancer, you’re likely to come across many treatments and medical terms. ADCs, or antibody-drug conjugates, are a kind of treatment option you might hear about. This guide will explain what ADCs are, how they may help with ovarian cancer and breast cancer, and how this knowledge can help you discuss treatment options with your doctor.

What are ADCs?

ADCs are medicines that are designed to work by targeting cancer cells. Because of this, some side effects of ADCs may be different from traditional chemotherapy. Imagine them as delivery trucks that can recognize harmful cells and bring the medicine to those cells. ADCs have been used in cancer treatment for over 20 years. More continue to be developed as treatments for many different cancers.

How do ADCs work?

ADCs are made to recognize and attach to certain proteins on cancer cells, and then enter the cells. Once an ADC is inside the cells, it releases a drug that kills them. The kinds of proteins that ADCs may recognize include biomarkers associated with ovarian cancer and breast cancer.

Why do ADCs matter for ovarian cancer and breast cancer?

Women with ovarian cancer or breast cancer may have tumors that are well suited for specific ADC treatments. Research shows that in the right patients, ADCs can help treat cancer cells.

Biomarker testing: An important first step to treatment

For ovarian and breast cancers, ADCs work by targeting specific biomarker proteins. Finding out—either when you are diagnosed or during your treatment journey—if your cancer has these specific biomarkers can help you and your doctor decide which treatments are best.

If you test positive for certain biomarkers, an ADC that is designed to work for your specific cancer could be an option.

The importance of self-advocacy

As you navigate your cancer treatment journey, remember that you are an important member of your healthcare team. Asking questions about possible treatment options you could be eligible for and interventions such as ADCs and biomarker testing may help you get the most appropriate care. Together with your doctor, you will be able to decide what is best for you.

Information provided by Sharsheret is not a substitute for medical advice or treatment and should not be used to diagnose or treat a health problem. Always seek the advice of your physician or qualified health provider.

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